Gridded Visualization of Statistical Trees for High-Dimensional Multipartite Data in Systems Genetics

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dc.contributor.authorAdams, Jane L.en_US
dc.contributor.authorBall, Robyn L.en_US
dc.contributor.authorBubier, Jason A.en_US
dc.contributor.authorChesler, Elissa J.en_US
dc.contributor.authorTory, Melanieen_US
dc.contributor.authorBorkin, Michelle A.en_US
dc.contributor.editorAigner, Wolfgangen_US
dc.contributor.editorAndrienko, Nataliaen_US
dc.contributor.editorWang, Beien_US
dc.date.accessioned2025-05-26T06:37:11Z
dc.date.available2025-05-26T06:37:11Z
dc.date.issued2025
dc.description.abstractIn systems genetics and other multi-omics research, exploring high-dimensional relationships among molecular and physiological variables across individuals poses significant challenges. We present the Gridded Trees interface, a novel interactive visualization tool designed to facilitate the exploration of conditional inference trees, which are hierarchical models of relationships in these complex datasets. Traditional static tools struggle to reveal patterns in tree-structured data, but the Gridded Trees interface provides interactive, coordinated views, allowing users to navigate between overview and detail, filter data dynamically, and compare molecular-physiological relationships across subgroups. By combining filtering techniques, strip plots, Sankey diagrams, and small multiples, the Gridded Trees interface enhances exploratory data analysis and supports hypothesis generation. In our systems genetics research use case, this tool has revealed significant associations among microbial populations and addiction-related behavioral traits in genetically diverse mice. The Gridded Trees interface suggests broad potential for visualizing hierarchical and multipartite data across domains. A preprint of this paper as well as Supplemental Materials are available on OSF at https://osf.io/9emn5/.en_US
dc.description.sectionheadersHonourable Mention
dc.description.seriesinformationComputer Graphics Forum
dc.identifier.doi10.1111/cgf.70113
dc.identifier.issn1467-8659
dc.identifier.pages12 pages
dc.identifier.urihttps://doi.org/10.1111/cgf.70113
dc.identifier.urihttps://diglib.eg.org/handle/10.1111/cgf70113
dc.publisherThe Eurographics Association and John Wiley & Sons Ltd.en_US
dc.rightsAttribution 4.0 International License
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleGridded Visualization of Statistical Trees for High-Dimensional Multipartite Data in Systems Geneticsen_US
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